Implication des micro-ARNs dans les dérégulations de l'érythropoïèse consécutives à l'insuffisance rénale chronique

E Hamza - 2022 - theses.hal.science
L'insuffisance rénale chronique (IRC) est un problème de santé mondial caractérisé par une
détérioration progressive de la fonction rénale. Elle est associée à des taux sériques élevés …

[HTML][HTML] 17AAG and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and ROS

T Walker, C Mitchell, MA Park, A Yacoub… - Molecular cancer …, 2010 - ncbi.nlm.nih.gov
The present studies determined in greater detail the molecular mechanisms upstream of the
CD95 death receptor by which geldanamycin HSP90 inhibitors and MEK1/2 inhibitors …

Deregulated Survival Pathways Confer Erythropoietin-Independent Survival and Proliferation in Erythroleukemia Progenitor Cells

M Morris - 2020 - search.proquest.com
Abnormal erythropoietin (Epo) signaling in erythroid precursor cells is a characteristic of
Acute Erythroid Leukemia (AEL). AEL is defined by the uncontrolled proliferation of …

Perturbing anti-apoptotic proteins to develop novel cancer therapies

J Contreras - 2017 - digitalcommons.unmc.edu
The apoptotic pathway involves a tightly regulated network of proteins which respond to
various stimuli. Previous studies have indicated Mcl-1 and Bcl-xL are intimately involved in …

[PDF][PDF] Hypoxia-related biological markers as predictors of epirubicin-based treatment responsiveness and resistance in locally advanced breast cancer

SB Gatter, D Generali, G Roviello - minerva-access.unimelb.edu.au
Purpose: To identify hypoxia-related biomarkers indicative of response and resistance to
epirubicin treatment in patients with locally advanced breast cancer. Patients and Methods …

[PDF][PDF] Synergistic Interactions between DMAG and Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitors in Bcr/abl Leukemia Cells Sensitive and Resistant to …

BJ Druker, P Dent, S Grant - academia.edu
Purpose: To characterize interactions between the heat shock protein 90 antagonist 17-
dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and the mitogen-activated …

[引用][C] Die protektive Wirkung von Erythropoietin in einem Neurodegenerationsmodell der neonatalen Ratte nach Hyperoxie Exposition

R Löber

Impact of growth factors, therapeutic inhibitors and cytostatic compounds on the response of non-small-cell lung carcinoma cell lines

R Merkle - 2015 - archiv.ub.uni-heidelberg.de
Lung cancer with its most prevalent form non-small-cell lung carcinoma (NSCLC) is one of
the leading causes of cancer-related deaths worldwide and is characterized by early …

Role of MAPK and NF-κB signalling pathways in the regulation of the human GM-CSF gene in normal and leukaemic blood cells

M Canestraro - 2015 - etheses.bham.ac.uk
GM-CSF is an important haematopoietic growth factor and immune modulator. Studies on T
cells revealed that efficient activation of the human GM-CSF gene is dependent upon the …

Keep dementia in mind, but forget memory formation: plasticity of the N-methyl-D-aspartate receptor in erythroid cells and its potential for the treatment of sickle cell …

P Hänggi - 2015 - zora.uzh.ch
Keep Dementia in Mind, but Forget Memory Formation: Plasticity of the N-Methyl-D-Aspartate
Receptor in Erythroid Cells and its P Page 1 Keep Dementia in Mind, but Forget Memory …