Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

Parkinson's disease is a neurodegenerative disease caused by the death of neurons, ie,
cells critical to the production of dopamine, an important neurotransmitter in the brain. Here …

This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …

Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …

ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental
physiological functions such as cell growth/development, cell survival, neuronal …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

Regulated cell death (RCD) is a ubiquitous process in living organisms that is essential for
tissue homeostasis or to restore biological balance under stress. Over the decades, various …

Traditional drug discovery focuses on identifying direct inhibitors of target proteins. This
typically relies on a measurable biochemical readout and accessible binding sites whose …