Tissue inhibitor of metalloproteinase 3 (TIMP3) is unique among the four TIMPs due to its
extracellular matrix (ECM)-binding property and broad range of inhibitory substrates that …

Ventricular remodeling (VR) is a complex pathological process of cardiomyocyte apoptosis,
cardiac hypertrophy, and myocardial fibrosis, which is often caused by various …

Despite the significant decline in mortality, cardiovascular diseases are still the leading
cause of death worldwide. Among them, myocardial infarction (MI) seems to be the most …

In the last 10 years, mortality from acute myocardial infarction (AMI) has not significantly
decreased. This situation is associated with the absence in clinical practice of highly …

Myocardial fibrosis (MF) is a reactive remodeling process in response to myocardial injury. It
is mainly manifested by the proliferation of cardiac muscle fibroblasts and secreting …

Despite diagnostic and therapeutic advances, coronary artery disease and especially its
extreme manifestation, ST elevation myocardial infarction (STEMI), remain the leading …

Fibrosis is a significant global health problem associated with many inflammatory and
degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis …

Background Mapping algorithms can be used to convert scores from a non-preference
based instrument to health state utilities. The objective of this study was to develop mapping …

MicroRNAs are small non-coding post-translational biomolecules which, when expressed,
modify their target genes. It is estimated that microRNAs regulate production of …

The significant reduction in 'ischemic time'through capillary diffusion of primary
percutaneous intervention (pPCI) has rendered myocardial-ischemia reperfusion injury …