Triple negative breast cancer (TNBC) continues to be the subtype of breast cancer with the
highest rates of recurrence and mortality. The lack of expression of targetable proteins such …

Background Accurate identification of pCR to neoadjuvant chemotherapy (NAC) is essential
for determining appropriate surgery strategy and guiding resection extent in breast cancer …

A better understanding of tumor biology and new drugs have led to significant changes in
the management of breast cancer (BC). Radical mastectomy, which had been the treatment …

The increased use of neoadjuvant chemotherapy (NACT) has changed the approach to
breast surgery. NACT allows de-escalation of surgery by both increasing breast …

Local treatment of the axilla in clinically node-negative (cN0) early breast cancer patients
with routine sentinel lymph node biopsy (SLNB) is debated after publication of ACOSOG …

Importance Patients should have an active role in decisions about pursuing or forgoing
specific therapies in treatment de-escalation trials. Objective To evaluate longitudinal patient …

The past two decades have seen an unprecedented trend towards de-escalation of surgical
therapy in the setting of early BC, the most prominent examples being the reduction of re …

Simple Summary The effectiveness of neoadjuvant treatment has led to an expansion of its
indications from locally advanced to highly chemo-sensitive early-stage breast cancers …

Objectives Response assessment to neoadjuvant systemic treatment (NAST) to guide
individualized treatment in breast cancer is a clinical research priority. We aimed to develop …

Background Understanding the survival outcomes associated with breast-conserving
therapy (BCT) and mastectomy after preoperative systemic therapy (PST) enables clinicians …