Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …

Although sex dimorphism is increasingly recognized as an important factor in pain, female-
specific pain signaling is not well studied. Here we report that administration of IL-23 …

Spontaneous pain refers to pain occurring without external stimuli. It is a primary complaint
in chronic pain conditions and remains difficult to treat. Moreover, the mechanisms …

Satellite glial cells (SGCs) are among the most abundant non-neuronal cells in dorsal root
ganglia (DRGs) and closely envelop sensory neurons that detect painful stimuli. However …

Chronic neuropathic pain (CNP) is caused by a lesion or disease of the somatosensory
nervous system. It affects~ 8% of the general population and negatively impacts a person's …

Microglia, resident immune cells in the central nervous system, play a role in
neuroinflammation and the development of neuropathic pain. We found that the stimulator of …

Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect
that occurs in up to 63% of patients and has no known effective treatment. A majority of …

Chronic low back pain is a common condition, with high societal costs and often ineffectual
treatments. Communication between macrophages/monocytes (MØ) and sensory neurons …

A peripheral injury drives neuroimmune interactions at the level of the injury and throughout
the neuraxis. Understanding these systems will be beneficial in the pursuit to target …