Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

In addition to physical barriers, neutrophils are considered a part of the first line of immune
defense. They can be found in the bloodstream, with a lifespan of 6–8 h, and in tissue …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

A direct association of islet-autoreactive T cells with β cell destruction in human pancreatic
islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known …

Aims/hypothesis Human pancreatic beta cells may be complicit in their own demise in type 1
diabetes, but how this occurs remains unclear. One potentially contributing factor is …

The Diabetes Virus Detection study (DiViD) is the first to examine fresh pancreatic tissue at
the diagnosis of type 1 diabetes for the presence of viruses. Minimal pancreatic tail resection …

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong
inflammatory component. The latest studies indicate that innate immunity and inflammatory …

APS1/APECED patients are defined by defects in the autoimmune regulator (AIRE) that
mediates central T cell tolerance to many self-antigens. AIRE deficiency also affects B cell …

Insulin-dependent diabetes mellitus (IDDM) is a chronic disorder that results from
autoimmune destruction of the insulin-producing pancreatic beta cells. Much has been …

Abstract Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic
individuals, and its expression and signaling are regulated by T1D genetic risk variants and …