Understanding the pathogenesis of type-I diabetes (T1D) is hindered in humans by the long
autoimmune process occurring before clinical onset and by the difficulty to study the …

Endocrine Effects of Nonhormonal Antineoplastic Therapy | Endocrine Reviews | Oxford
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Increasing evidence suggests that type 1 IFN (IFN-αβ) is associated with pathogenesis of
Th1-mediated type 1 diabetes (T1D). A major source of IFN-αβ is plasmacytoid dendritic …

Techniques were developed to look for evidence of viral infection in formalin-fixed paraffin-
embedded autopsy pancreatic tissues from patients who had died of recent-onset insulin …

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by
pancreatic islet inflammation (insulitis) and specific pancreatic β-cell destruction by an …

Therapeutic antibodies directed against tumor necrosis factor alpha (TNF-α) for the
treatment of rheumatoid arthritis, and against the human EGF receptor-2 (HER2) receptor for …

Abstract Type 1 diabetes (T1D) is caused by autoimmune destruction of pancreatic β cells.
Mounting evidence supports a central role for β cell alterations in triggering the activation of …

Enteroviruses (EVs) have long been implicated in the pathogenesis of type 1 diabetes
(T1D), and accumulating evidence has associated virus-induced autoimmunity with the loss …

Summary OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW
SERIES Metabolic diseases, host responses, cancer, autoinflammatory diseases, allergy …

Autoimmunizing mechanisms are very hard to study in humans, so we have focused on vital
clues in thymomas and hyperplastic thymuses in myasthenia gravis (MG). According to our …