We earlier proposed that a human endogenous retroviral (HERV) superantigen (SAg)
IDDMK 1, 2 22 may cause type I diabetes by activating autoreactive T cells. Viral infections …

Abstract Type 1 diabetes (T1D) results from genetic predisposition and environmental
factors leading to the autoimmune destruction of pancreatic beta cells. Recently, a rapid …

Mitochondria, in symbiosis with the host cell, carry out a wide variety of functions from
generating energy, regulating the metabolic processes, cell death to inflammation. The most …

Type 1 diabetes (T1D) is classically characterised by the clinical need for insulin, the
presence of disease-associated serum autoantibodies, and an onset in childhood. The …

Viral infections have previously been implicated as a trigger of autoimmune diabetes. In this
study, we compared a viral mimic with other microbial components derived from bacteria in …

Enteroviruses (EV) have been historically associated to type 1 diabetes. Definitive proof for
their implication in disease development is lacking, but growing evidence suggests that they …

The field of Type 1 diabetes research has been quick to embrace the era of translational
medicine in the recent epoch. Building upon some 30 years of intense immunological …

Type 1 diabetes (T1D) is a disease characterized by inflammation of pancreatic islets
associated with autoimmunity against insulin‐producing beta cells, leading to their …

Environmental factors, especially viruses, are thought to play an important role in the
initiation or acceleration of the pathogenesis of type 1 diabetes (T1D). Data from …

Type 1 diabetes is an insulin-dependent, autoimmune disease where the pancreatic β cells
are destroyed resulting in hyperglycemia. This multifactorial disease involves multiple …