Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …

Lignocellulosic biomass (LCB) has been recognized as a valuable carbon source for the
sustainable production of biofuels and value-added biochemicals. Crude enzymes …

Ferroptosis is the type of cell death arising from uncontrolled and excessive lipid
peroxidation. NADPH is essential for ferroptosis regulation because it supplies reducing …

SEL1L-mediated endoplasmic reticulum-associated degradation (ERAD) plays critical roles
in controlling protein homeostasis by degrading misfolded or terminal unfolded proteins …

Protein misfolding is a major factor of neurodegenerative diseases. Post-mitotic neurons are
highly susceptible to protein aggregates that are not diluted by mitosis. Therefore, post …

Conserved catabolic pathways operate to remove aberrant polypeptides from the
endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best …

The metabolic prohormone pro-opiomelanocortin (POMC) is generally translocated into the
endoplasmic reticulum (ER) for entry into the secretory pathway. Patients with mutations …

Abstract Doa10 (MARCHF6 in metazoans) is a large polytopic membrane-embedded E3
ubiquitin ligase in the endoplasmic reticulum (ER) that plays an important role in quality …

GRP170 (Hyou1) is required for mouse embryonic development, and its ablation in kidney
nephrons leads to renal failure. Unlike most chaperones, GRP170 is the lone member of its …

Selenoprotein S (selenos) is a small, intrinsically disordered membrane protein that is
associated with various cellular functions, such as inflammatory processes, cellular stress …