Sleep deprivation drives brain-wide changes in cholinergic presynapse abundance in Drosophila melanogaster

JT Weiss, MZ Blundell, P Singh… - Proceedings of the …, 2024 - National Acad Sciences
Sleep is an evolutionarily conserved state that supports brain functions, including synaptic
plasticity, in species across the animal kingdom. Here, we examine the neuroanatomical …

Brain wiring determinants uncovered by integrating connectomes and transcriptomes

J Yoo, M Dombrovski, P Mirshahidi, A Nern… - Current Biology, 2023 - cell.com
Advances in brain connectomics have demonstrated the extraordinary complexity of neural
circuits. 1, 2, 3, 4, 5 Developing neurons encounter the axons and dendrites of many …

SynLight: a bicistronic strategy for simultaneous active zone and cell labeling in the Drosophila nervous system

MA Aimino, J Humenik, MJ Parisi… - G3: Genes …, 2023 - academic.oup.com
At synapses, chemical neurotransmission mediates the exchange of information between
neurons, leading to complex movement, behaviors, and stimulus processing. The immense …

Glia control experience-dependent plasticity in an olfactory critical period

HC Leier, AJ Foden, DA Jindal, AJ Wilkov… - bioRxiv, 2024 - biorxiv.org
Sensory experience during developmental critical periods has lifelong consequences for
circuit function and behavior, but the molecular and cellular mechanisms through which …

A closer look at the synapse: dlg1 [4K] enables cell-specific visualization of PSD-95/DLG1

EL Hendricks, FLW Liebl - Cell Reports Methods, 2023 - cell.com
The PSD-95 homolog, DLG1, is important for excitatory synapse structure and function
throughout the Drosophila nervous system. In this issue of Cell Reports Methods, Parisi et al …

Axon arrival times and physical occupancy establish visual projection neuron integration on developing dendrites in the Drosophila optic glomeruli

BW McFarland, HJ Jang, N Smolin, BW Hina, MJ Parisi… - bioRxiv, 2022 - biorxiv.org
Behaviorally relevant, higher order representations of an animal's environment are built from
the convergence of visual features encoded in the early stages of visual processing …