Multicellular organisms rely on cell adhesion molecules to coordinate cell–cell interactions,
and to provide navigational cues during tissue formation. In Drosophila, Fasciclin 2 (Fas2) …

Control of protein abundance by the ubiquitin–proteasome system is essential for normal
brain development and function. Just over a decade ago, the first post-mitotic function of the …

The Drosophila egg chamber comprises a germline cyst surrounded by a tightly organised
epithelial monolayer, the follicular epithelium (FE). Loss of integrin function from the FE …

The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit, multifunctional
ubiquitin ligase that controls the temporal degradation of numerous cell cycle regulatory …

Axon growth is an essential event during brain development and is extremely limited due to
extrinsic and intrinsic inhibition in the adult brain. The E3 ubiquitin ligase Cdh1-anaphase …

The anaphase promoting complex/cyclosome (APC/C) is an E3 ligase regulated by Cdh1.
Beyond its role in controlling cell cycle progression, APC/C–Cdh1 has been detected in …

The development of tissues and organs requires close interaction of cells. To achieve this,
cells express adhesion proteins such as the neural cell adhesion molecule (NCAM) or its …

In recent years, diverse and unexpected neurobiological functions have been uncovered for
the major cell cycle-regulated ubiquitin ligase, the anaphase-promoting complex (APC) …

Much confusion surrounds the physiological function of the cellular prion protein (PrPC). It is,
however, anticipated that knowledge of its function will shed light on its contribution to …

A population of Drosophila adult tracheal progenitor cells arises from differentiated cells of
the larval main trachea that retain the ability to reenter the cell cycle and give rise to the …