Degradation of endocytosed proteins involves the formation of transient connections
between late endosomes and lysosomes in a process called" kiss and run." Genes and …

Trans-cellular communication relies on a complex interplay of cell–cell adhesion and
signaling induced by diffusible molecules. This is particularly evident for neuron–glia …

Human PRICKLE1 gene has been associated with epilepsy. However, the underlying
pathogenetic mechanisms remain elusive. Here we report a Drosophila prickle mutant pk …

Cell migration and guidance are complex processes required for morphogenesis, the
formation of tumor metastases, and the progression of human cancer. During migration …

Abstract Single-minded 2 (Sim2) gene, located at the Down syndrome (DS) critical region, is
thought to be particularly important because of its critical role in the development of the …

Anaphase-promoting complex (APC) and its co-activator Cdh1 are required for cell cycle
regulation in proliferating cells. Recent studies have defined diverse functions of APC–Cdh1 …

Development of the adult olfactory system of the moth Manduca sexta depends on reciprocal
interactions between olfactory receptor neuron (ORN) axons growing in from the periphery …

The coordination of neuronal and glial migration is essential to the formation of most
nervous systems, requiring a complex interplay of cell-intrinsic responses and intercellular …

The Drosophila compound eye comprises about 750 individual ommatidia arranged into an
almost crystalline array. The eye is not needed for viability and thus served as a favorite …

The development of the nervous system requires tight control of cell division, fate
specification and migration. The anaphase-promoting complex/cyclosome (APC/C) is an E3 …