3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice

AD Rathnayake, J Zheng, Y Kim, KD Perera… - Science translational …, 2020 - science.org
Pathogenic coronaviruses are a major threat to global public health, as exemplified by
severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory …

Nucleotide analogues as inhibitors of SARS-CoV-2 polymerase, a key drug target for COVID-19

M Chien, TK Anderson, S Jockusch, C Tao… - Journal of proteome …, 2020 - ACS Publications
SARS-CoV-2 is responsible for the current COVID-19 pandemic. On the basis of our
analysis of hepatitis C virus and coronavirus replication, and the molecular structures and …

Drug development and medicinal chemistry efforts toward SARS‐coronavirus and Covid‐19 therapeutics

AK Ghosh, M Brindisi, D Shahabi… - …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming
rate and has created an unprecedented health emergency around the globe. There is no …

The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2

NS Ogando, JC Zevenhoven-Dobbe… - Journal of …, 2020 - Am Soc Microbiol
Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …

The middle east respiratory syndrome (MERS)

EI Azhar, DSC Hui, ZA Memish, C Drosten… - Infectious Disease …, 2019 - id.theclinics.com
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a new zoonotic human
viral pathogen endemic to the Middle East. 1–3 It was identified in 2012 in a lung sample of …

[PDF][PDF] Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects

YW Cheng, TL Chao, CL Li, MF Chiu, HC Kao… - Cell reports, 2020 - cell.com
Development of specific antiviral agents is an urgent unmet need for SARS-coronavirus 2
(SARS-CoV-2) infection. This study focuses on host proteases that proteolytically activate …

Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms

R Butowt, K Bilinska, CS von Bartheld - Trends in neurosciences, 2023 - cell.com
The mechanisms of olfactory dysfunction in COVID-19 are still unclear. In this review, we
examine potential mechanisms that may explain why the sense of smell is lost or altered …

Analysis of the susceptibility to COVID-19 in pregnancy and recommendations on potential drug screening

X Zhao, Y Jiang, Y Zhao, H Xi, C Liu, F Qu… - European Journal of …, 2020 - Springer
To analyze the susceptibility of SARS-CoV-2 in pregnancy and the drugs that can be used to
treat pregnancy with COVID-19, so as to provide evidence for drug selection in clinic. By …

COVID-19 por SARS-CoV-2: la nueva emergencia de salud

R Aragón-Nogales, I Vargas-Almanza… - Revista mexicana de …, 2019 - scielo.org.mx
Los coronavirus se encuentran ampliamente distribuidos e infectan humanos, mamíferos y
aves, pueden ocasionar enfermedades respiratorias, entéricas, hepáticas y neurológicas …

Putative inhibitors of SARS-CoV-2 main protease from a library of marine natural products: a virtual screening and molecular modeling study

D Gentile, V Patamia, A Scala, MT Sciortino, A Piperno… - Marine drugs, 2020 - mdpi.com
The current emergency due to the worldwide spread of the COVID-19 caused by the new
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great concern for …