The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …

Cell death can be executed through distinct subroutines. PANoptosis is a unique
inflammatory cell death modality involving the interactions between pyroptosis, apoptosis …

With cardiovascular disease (CVD) being a primary source of global morbidity and mortality,
it is crucial that we understand the molecular pathophysiological mechanisms at play …

Abstract Tumor-associated macrophages (TAMs), as a major and essential component of
tumor microenvironment (TME), play a critical role in orchestrating pancreatic cancer (PaC) …

Vascular diseases constitute a significant contributor to worldwide mortality rates, placing a
substantial strain on healthcare systems and socio-economic aspects. They are closely …

Summary Na+/K+-ATPase (NKA) plays an important role in the central nervous system.
However, little is known about its function in the microglia. Here, we found that NKAα1 forms …

Traumatic brain injury (TBI) affects not only the brain but also peripheral organs like the
heart and the lungs, which influences long-term outcomes. A heightened systemic …

Background The renal sympathetic nervous system modulates systemic blood pressure,
cardiac performance, and renal function. Pathological increases in renal sympathetic nerve …

Inflammation plays an important role in the pathophysiology of cardiometabolic diseases.
Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP) …

Despite enormous global efforts within clinical research and medical practice to reduce
cardiovascular disease (s)(CVD), it still remains the leading cause of death worldwide. While …