Oncolytic virotherapy: basic principles, recent advances and future directions

D Lin, Y Shen, T Liang - Signal transduction and targeted therapy, 2023 - nature.com
Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they
are generally considered to have direct oncolysis and cancer immune effects. With the …

Adenovirus biology, recombinant adenovirus, and adenovirus usage in gene therapy

M Watanabe, Y Nishikawaji, H Kawakami, K Kosai - Viruses, 2021 - mdpi.com
Gene therapy is currently in the public spotlight. Several gene therapy products, including
oncolytic virus (OV), which predominantly replicates in and kills cancer cells, and COVID-19 …

Mesenchymal stem cells: A new platform for targeting suicide genes in cancer

R Moradian Tehrani, J Verdi… - Journal of cellular …, 2018 - Wiley Online Library
One of the important strategies for the treatment of cancer is gene therapy which has the
potential to exclusively eradicate malignant cells, without any damage to the normal tissues …

[HTML][HTML] Oncolytic adenovirus—a nova for gene-targeted oncolytic viral therapy in HCC

M Abudoureyimu, Y Lai, C Tian, T Wang… - Frontiers in …, 2019 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide, particularly
in China. Despite the development of HCC treatment strategies, the survival rate remains …

Systemic administration of mesenchymal stem cells loaded with a novel oncolytic adenovirus carrying IL-24/endostatin enhances glioma therapy

J Zhang, H Chen, C Chen, H Liu, Y He, J Zhao, P Yang… - Cancer Letters, 2021 - Elsevier
Oncolytic adenovirus-mediated gene therapy shows promise for cancer treatment; however,
the systemic delivery of oncolytic adenovirus to tumors remains challenging. Recently …

[HTML][HTML] Progress and application of intelligent nanomedicine in urinary system tumors

Y Xiao, L Zhong, J Liu, L Chen, Y Wu, G Li - Journal of Pharmaceutical …, 2024 - Elsevier
Urinary system tumors include malignancies of the bladder, kidney, and prostate, and
present considerable challenges in diagnosis and treatment. The conventional therapeutic …

Physiologically stable F127-GO supramolecular hydrogel with sustained drug release characteristic for chemotherapy and photothermal therapy

B Li, L Zhang, Z Zhang, R Gao, H Li, Z Dong, Q Wang… - RSC …, 2018 - pubs.rsc.org
A synthetic method for preparing a Pluronic F127 (F127)-stabilized graphene (GO)
supramolecular hydrogel as a safe nanovehicle for combination treatment has been studied …

Inhibition of human adenovirus replication by TRIM35-mediated degradation of E1A

N Sun, J Zhang, C Zhang, T Xie, Z Zhang… - Journal of …, 2023 - Am Soc Microbiol
Human adenovirus (HAdV) is ubiquitous in the human population, constituting a significant
burden of global respiratory diseases. Children and individuals with low immunity are at risk …

Recent advances of engineered oncolytic viruses-based combination therapy for liver cancer

J Zhang, Y Xiao, J Zhang, Y Yang, L Zhang… - Journal of Translational …, 2024 - Springer
Liver cancer is a major malignant tumor, which seriously threatens human health and
increases the economic burden on patients. At present, gene therapy has been …

A New HEK293 Cell with CR2 Region of E1A Gene Deletion Prevents the Emergence of Replication-Competent Adenovirus

X Lian, X Zhao, J Zhong, C Zhang, Y Chu, Y Wang… - Cancers, 2023 - mdpi.com
Simple Summary During high titer recombinant oncolytic adenovirus production, Replication-
Competent Adenovirus (RCA) contaminants can be generated through recombination …