[HTML][HTML] Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment
Radiation therapy is an effective cancer treatment, although damage to healthy tissues is
common. Here we analyzed cell-free, methylated DNA released from dying cells into the …
common. Here we analyzed cell-free, methylated DNA released from dying cells into the …
The DNA methylome of human vascular endothelium and its use in liquid biopsies
Summary Background: Vascular endothelial cells (VECs) are an essential component of
each tissue, contribute to multiple pathologies, and are targeted by important drugs. Yet …
each tissue, contribute to multiple pathologies, and are targeted by important drugs. Yet …
A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease
BS Summers, S Thomas Broome… - International …, 2024 - journals.sagepub.com
Stem cells are ubiquitously found in various tissues and organs in the body, and underpin
the body's ability to repair itself following injury or disease initiation, though repair can …
the body's ability to repair itself following injury or disease initiation, though repair can …
Single-cell sequencing reveals the existence of fetal vascular endothelial stem cell-like cells in mouse liver
FN Rahmawati, T Iba, H Naito, S Shimizu… - Stem Cell Research & …, 2023 - Springer
Background A resident vascular endothelial stem cell (VESC) population expressing CD157
and CD200 has been identified recently in the adult mouse. However, the origin of this …
and CD200 has been identified recently in the adult mouse. However, the origin of this …
Membrane properties of human induced pluripotent stem cell-derived cultured red blood cells
Cultured red blood cells from human induced pluripotent stem cells (cRBC_iPSCs) are a
promising source for future concepts in transfusion medicine. Before cRBC_iPSCs will have …
promising source for future concepts in transfusion medicine. Before cRBC_iPSCs will have …
A literature-derived knowledge graph augments the interpretation of single cell RNA-seq datasets
D Doddahonnaiah, PJ Lenehan, TK Hughes… - Genes, 2021 - mdpi.com
Technology to generate single cell RNA-sequencing (scRNA-seq) datasets and tools to
annotate them have advanced rapidly in the past several years. Such tools generally rely on …
annotate them have advanced rapidly in the past several years. Such tools generally rely on …
The role of microRNAs in defining LSECs cellular identity and in regulating F8 gene expression
MA Jamil, R Al-Rifai, N Nuesgen, J Altmüller… - Frontiers in …, 2024 - frontiersin.org
Introduction: Coagulation Factor VIII (FVIII) plays a pivotal role in the coagulation cascade,
and deficiencies in its levels, as seen in Hemophilia A, can lead to significant health …
and deficiencies in its levels, as seen in Hemophilia A, can lead to significant health …
Cell-free, methylated DNA in blood samples reveals tissue-specific, cellular damage from radiation treatment
ME Barefoot, N Loyfer, AJ Kiliti, MO Schmidt… - bioRxiv, 2022 - biorxiv.org
Radiation therapy is an effective cancer treatment although damage to healthy tissues is
common. Here we characterize the methylomes of healthy human and mouse tissues to …
common. Here we characterize the methylomes of healthy human and mouse tissues to …
Spatial Computational Hepatic Molecular Biomarker Reveals LSEC Role in Midlobular Liver Zonation Fibrosis in DILI and NASH Liver Injury
M Puri - International Journal of Translational Medicine, 2024 - mdpi.com
The liver is structurally organized into zonation, where Liver Sinusoidal Endothelial Cells
(LSECs) play a crucial role during chronic liver injury and the early stages of fibrosis …
(LSECs) play a crucial role during chronic liver injury and the early stages of fibrosis …