Decades of research have characterized diverse immune cells surveilling the CNS. More
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …

Sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG) are
specialized to detect and transduce diverse environmental stimuli to the central nervous …

The discoveries that cerebrospinal fluid participates in metabolic perivascular exchange with
the brain and further drains solutes to meningeal lymphatic vessels have sparked a …

The pathophysiological underpinnings of critically disrupted brain connectomes resulting in
coma are poorly understood. Inflammation is potentially an important but still undervalued …

Activating autologous stem cells after the implantation of biomaterials is an important
process to initiate bone regeneration. Although several studies have demonstrated the …

In multiple sclerosis (MS), there is a great need for treatment with the ability to suppress
compartmentalized inflammation within the central nervous system (CNS) and to promote …

The brain and spinal cord collectively referred to as the Central Nervous System (CNS) are
protected by the blood-brain barrier that limits molecular, microbial and immunological …

Mammalian brain border-associated macrophages (BAMs) are strategically positioned to
support vital properties and processes: for example, the composition of the brain's …

This paper provides an overview of the role of neuroinflammation in Alzheimer's disease
and other neurodegenerative diseases, highlighting the potential of anti-inflammatory …

The recent identification of skull bone marrow as a reactive hematopoietic niche that can
contribute to and direct leukocyte trafficking into the meninges and brain has transformed …