Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …

Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Abstract γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …

Polyamines are essential for the growth and proliferation of mammalian cells and are
intimately involved in biological mechanisms such as DNA replication, RNA transcription …

Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

Chronic sleep loss profoundly impacts metabolic health and shortens lifespan, but studies of
the mechanisms involved have focused largely on acute sleep deprivation. 1, 2 To identify …

Astrocyte abnormalities have received great attention for their association with various
diseases in the brain but not so much in the eye. Recent independent genome-wide …

Microbiota dysbiosis and metabolic syndrome, consequences of a non-adequate diet,
generate a feedback pathogenic state implicated in Alzheimer's disease development. The …

This review examines the role of impaired amyloid-β clearance in the accumulation of
amyloid-β in the brain and the periphery, which is closely associated with Alzheimer's …

Introduction Vascular dementia (VaD) is one of the most common causes of dementia
among the elderly. Despite this, the molecular basis of VaD remains poorly characterized …