Demographic risk factors, inspection of the pancreas by an experienced surgeon and
predicted CIT are crucial factors in deciding whether to accept a pancreas for …

One of the main factors limiting potential uptake of pancreas transplantation, particularly in
the United Kingdom, is the shortage of grafts. There has therefore been a recent expansion …

Tauopathies are a class of neurodegenerative disorders characterized by abnormal
deposition of post-translationally modified tau protein in the human brain. Tauopathies are …

Ischemic stroke is the primary cause of disability and mortality worldwide.
Ischemia/reperfusion (I/R)-induced microcirculatory dysfunction and organ injury generally …

Background Islet transplantation is an effective therapy in type 1 diabetes and recalcitrant
hypoglycemia. However, there is an ongoing need to circumvent islet loss posttransplant …

Aims/hypothesis Approximately 50% of organ donors develop hyperglycaemia in intensive
care, which is managed with insulin therapy. We aimed to determine the relationships …

Background. Ischemia/reperfusion (I/R) injury after pancreas transplantation might result in
graft pancreatitis. The role of heme oxygenase-1 (HO-1) in pancreas transplantation and …

Depletion of the nitric oxide synthase cofactor tetrahydrobiopterin (H4B) during ischemia
and reperfusion is associated with severe graft pancreatitis. Since clinically feasible …

This study assessed the effects of a two-layer method (TLM), using perfluorocarbon and UW
solution, on the quality of human pancreata following storage and islet yield/function after …

Background. The aim of this study was to identify genes that are differentially expressed in
the early period after pancreatic cold ischemia/reperfusion (I/R) injury. Methods. Grafts of …