Alternative splicing and related RNA binding proteins in human health and disease

Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

RNA splicing factor RBFOX2 is a key factor in the progression of cancer and cardiomyopathy

J Shen, J Shentu, C Zhong, Q Huang… - Clinical and …, 2024 - Wiley Online Library
Background Alternative splicing of pre‐mRNA is a fundamental regulatory process in
multicellular eukaryotes, significantly contributing to the diversification of the human …

A novel electrochemical immunosensor based on AuNPs/PNR/CS@ MWCNTs-COOH for rapid detecting warning markers-BNP of heart failure caused by myocardial …

Y Liu, B Sun, Y Wu, H Li, D Li, Q Dang, S Liu, X Da… - Microchemical …, 2024 - Elsevier
Heart failure (HF) is an insidious and dangerous disease that significantly impairs a patient's
quality of life and safety. It is not easy to detect in mild cases, and once it progresses to …

[HTML][HTML] Significance of microRNA-targeted ErbB signaling pathway genes in cardiomyocyte differentiation

A Gholipour, A Zahedmehr, F Shakerian, S Irani… - Molecular and cellular …, 2023 - Elsevier
Objective (s) Cardiomyocyte differentiation is a complex process that follows the progression
of gene expression alterations. The ErbB signaling pathway is necessary for various stages …

Bioinformatics and next generation data analysis reveals the potential role of inflammation in sepsis and its associated complications

B Vastrad, C Vastrad - bioRxiv, 2023 - biorxiv.org
Sepsis is the leading systemic inflammatory response syndrome in worldwide, yet relatively
little is known about the genes and signaling pathways involved in sepsis progression. The …

Enhanced isradipine sensitivity in vascular smooth muscle cells due to hypoxia‐induced Cav1.2 splicing and RbFox1/Fox2 downregulation

CP Poore, J Yang, S Wei, CK Fhu, Z Bichler… - The FEBS … - Wiley Online Library
Calcium influx via the L‐type voltage‐gated Cav1. 2 calcium channel in smooth muscle cells
regulates vascular contraction. Calcium channel blockers (CCBs) are widely used to treat …