Evolving therapeutic landscape of advanced hepatocellular carcinoma

C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …

Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits

M Peiseler, R Schwabe, J Hampe, P Kubes… - Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

[HTML][HTML] Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer

DQ Huang, AG Singal, Y Kono, DJH Tan, HB El-Serag… - Cell metabolism, 2022 - cell.com
Liver cancer epidemiology is changing due to increasing alcohol consumption, rising
prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) …

[HTML][HTML] Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors

DQ Huang, P Mathurin, H Cortez-Pinto… - Nature reviews …, 2023 - nature.com
Heavy alcohol consumption is a major cause of morbidity and mortality. Globally, alcohol per-
capita consumption rose from 5.5 litres in 2005 to 6.4 litres in 2016 and is projected to …

The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma

R Donne, A Lujambio - Hepatology, 2023 - journals.lww.com
The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …

Hepatobiliary cancers, version 2.2021, NCCN clinical practice guidelines in oncology

AB Benson, MI D'Angelica, DE Abbott… - Journal of the National …, 2021 - jnccn.org
The NCCN Guidelines for Hepatobiliary Cancers focus on the screening, diagnosis, staging,
treatment, and management of hepatocellular carcinoma (HCC), gallbladder cancer, and …

[HTML][HTML] Rapid, label-free histopathological diagnosis of liver cancer based on Raman spectroscopy and deep learning

L Huang, H Sun, L Sun, K Shi, Y Chen, X Ren… - Nature …, 2023 - nature.com
Biopsy is the recommended standard for pathological diagnosis of liver carcinoma.
However, this method usually requires sectioning and staining, and well-trained pathologists …

Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020

W Cao, HD Chen, YW Yu, N Li, WQ Chen - Chinese medical journal, 2021 - mednexus.org
Background: Cancer is one of the leading causes of death globally, but its burden is not
uniform. GLOBOCAN 2020 has newly updated the estimates of cancer burden. This study …

[HTML][HTML] Exosome-derived circCCAR1 promotes CD8+ T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

Z Hu, G Chen, Y Zhao, H Gao, L Li, Y Yin, J Jiang… - Molecular cancer, 2023 - Springer
Abstract Background Circular RNAs (circRNAs) can be encapsulated into exosomes to
participate in intercellular communication, affecting the malignant progression of a variety of …

Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention

DQ Huang, HB El-Serag, R Loomba - Nature reviews Gastroenterology …, 2021 - nature.com
One quarter of the global population is estimated to have nonalcoholic fatty liver disease
(NAFLD). The incidence of nonalcoholic steatohepatitis (NASH) is projected to increase by …