[HTML][HTML] Antimicrobial peptides: A new hope in biomedical and pharmaceutical fields

A Moretta, C Scieuzo, AM Petrone, R Salvia… - Frontiers in cellular …, 2021 - frontiersin.org
Antibiotics are essential drugs used to treat pathogenic bacteria, but their prolonged use
contributes to the development and spread of drug-resistant microorganisms. Antibiotic …

[HTML][HTML] Antimicrobial peptides: an emerging category of therapeutic agents

M Mahlapuu, J Håkansson, L Ringstad… - Frontiers in cellular and …, 2016 - frontiersin.org
Antimicrobial peptides (AMPs), also known as host defense peptides, are short and
generally positively charged peptides found in a wide variety of life forms from …

Computer-aided design of antimicrobial peptides: are we generating effective drug candidates?

MH Cardoso, RQ Orozco, SB Rezende… - Frontiers in …, 2020 - frontiersin.org
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …

Antimicrobial peptides in 2014

G Wang, B Mishra, K Lau, T Lushnikova, R Golla… - Pharmaceuticals, 2015 - mdpi.com
This article highlights new members, novel mechanisms of action, new functions, and
interesting applications of antimicrobial peptides reported in 2014. As of December 2014 …

Mechanisms and regulation of defensins in host defense

J Fu, X Zong, M Jin, J Min, F Wang… - Signal Transduction and …, 2023 - nature.com
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

Perspectives for clinical use of engineered human host defense antimicrobial peptides

ME Pachón-Ibáñez, Y Smani, J Pachon… - FEMS microbiology …, 2017 - academic.oup.com
Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of
death worldwide. The emergence of drug-resistance mechanisms, especially among …

Gold nanoparticle-DNA aptamer conjugate-assisted delivery of antimicrobial peptide effectively eliminates intracellular Salmonella enterica serovar Typhimurium

JH Yeom, B Lee, D Kim, J Lee, S Kim, J Bae, Y Park… - Biomaterials, 2016 - Elsevier
Antimicrobial peptides (AMPs) are a promising new class of antibacterial compounds.
However, their applications in the treatment of intracellular pathogenic bacteria have been …

Mammalian antimicrobial peptides: promising therapeutic targets against infection and chronic inflammation

P Dutta, S Das - Current topics in medicinal chemistry, 2016 - ingentaconnect.com
Antimicrobial peptides (AMPs) are integral components of the host innate immune system
and functional throughout the plant and animal kingdoms. AMPs are short cationic …

[HTML][HTML] Evolutionary diversification of defensins and cathelicidins in birds and primates

A van Dijk, R Guabiraba, G Bailleul, C Schouler… - Molecular …, 2023 - Elsevier
Divergent evolution for more than 310 million years has resulted in an avian immune system
that is complex and more compact than that of primates, sharing much of its structure and …

Application of antimicrobial peptides as next-generation therapeutics in the biomedical world

M Datta, A Rajeev, I Chattopadhyay - Biotechnology and Genetic …, 2023 - Taylor & Francis
Antimicrobial peptide (AMP), also called host defense peptide, is a part of the innate immune
system in eukaryotic organisms. AMPs are also produced by prokaryotes in response to …