In pancreatic β-cells, the endoplasmic reticulum (ER) is an important cellular compartment
for insulin biosynthesis, which accounts for half of the total protein production in these cells …

Systemic messenger RNA (mRNA) delivery to organs outside the liver, spleen, and lungs
remains challenging. To overcome this issue, we hypothesized that altering nanoparticle …

Since the initial reporting of the successful reversal of hyperglycemia through the
transplantation of pancreatic islets, significant research efforts have been conducted in …

Transplantation of donor-derived islets into the liver is a successful cellular replacement
therapy for individuals with diabetes. However, the hepatic vasculature is not an optimal …

Islet transplantation is a promising alternative therapy for insulin-dependent patients, with
the potential to eliminate life-threatening hypoglycemic episodes and secondary …

Background. Bone marrow-derived mesenchymal stem cells (MSCs) are known to produce
vascular endothelial growth factor. We hypothesize that co-transplantation of MSCs and …

Pancreatic islet transplantation still represents a promising therapeutic strategy for curative
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …

Maintaining long-term euglycemia after intraportal islet transplantation is hampered by the
considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and …

Type 1 diabetes (T1DM) affects one in every 400 children and adolescents in the US. Due to
the limitations of exogenous insulin therapy and whole pancreas transplantation, pancreatic …

This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …