The price of human evolution: Cancer-testis antigens, the decline in male fertility and the increase in cancer

J Erenpreisa, NM Vainshelbaum, M Lazovska… - International Journal of …, 2023 - mdpi.com
The increasing frequency of general and particularly male cancer coupled with the reduction
in male fertility seen worldwide motivated us to seek a potential evolutionary link between …

[HTML][HTML] Cancer as a global health crisis with deep evolutionary roots

RJ Klement - Global Transitions, 2024 - Elsevier
The global burden of cancer incidence, deaths and economic costs is steadily increasing
since several decades. Despite a massive allocation of research funds since the 1970s, no …

Special Issue “Advances in Genome Regulation in Cancer”

J Erenpreisa, A Giuliani, MS Cragg - International Journal of Molecular …, 2023 - mdpi.com
Cancer is globally increasing. Since 2010 it has risen in incidence by 26.3%, with mortality
growing by 20.9% and cancer-associated invalidity increasing by 16.0%[1], painfully …

Tetraploidization Increases the Motility and Invasiveness of Cancer Cells

M Jemaà, R Daams, S Charfi, F Mertens… - International Journal of …, 2023 - mdpi.com
Polyploidy and metastasis are associated with a low probability of disease-free survival in
cancer patients. Polyploid cells are known to facilitate tumorigenesis. However, few data …

Polyploidy Promotes Hypertranscription, Apoptosis Resistance, and Ciliogenesis in Cancer Cells and Mesenchymal Stem Cells of Various Origins: Comparative …

OV Anatskaya, AE Vinogradov - International Journal of Molecular …, 2024 - mdpi.com
Mesenchymal stem cells (MSC) attract an increasing amount of attention due to their unique
therapeutic properties. Yet, MSC can undergo undesirable genetic and epigenetic changes …

[HTML][HTML] Tetraploidy as a metastable state towards malignant cell transformation within a systemic approach of cancer development

M Kirsch-Volders, M Mišík, J de Gerlache - Mutation Research-Genetic …, 2024 - Elsevier
Tetraploidy, a condition in which a cell has four homologous sets of chromosomes, may be a
natural physiological condition or pathophysiological such as in cancer cells or stress …

[PDF][PDF] Advances in genome regulation in cancer

J Erenpreisa, A Giuliani… - International Journal of …, 2023 - eprints.soton.ac.uk
Cancer is globally increasing. Since 2010 it has risen in incidence by 26.3%, with mortality
growing by 20.9% and cancer-associated invalidity increasing by 16.0%[1], painfully …

Malignances Stage Development in vitro: The Role of (Very) Small Cancer and Leukemic Stem-Like Cells

JJ Lica, J Jakóbkiewicz-Banecka, A Hellmann - 2024 - preprints.org
Abstract Simple Summary: This review explores the origin of Leukemic Stem-Like Cells
(LSLCs) from (Very) Small Leukemic Stem-Like Cells ((V) SLSLCs) and Cancer Stem Cells …

[PDF][PDF] Global Transitions

RJ Klement - researchgate.net
abstract The global burden of cancer incidence, deaths and economic costs is steadily
increasing since several decades. Despite a massive allocation of research funds since the …