PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond

S Fattahi, F Amjadi-Moheb, R Tabaripour, GH Ashrafi… - Life Sciences, 2020 - Elsevier
Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …

LncRNAs as potential diagnostic and prognostic biomarkers in gastric cancer: a novel approach to personalized medicine

S Fattahi, M Kosari‐Monfared… - Journal of cellular …, 2020 - Wiley Online Library
Gastric cancer is the third leading cause of cancer death with 5‐year survival rate of about
30–35%. Since early detection is associated with decreased mortality, identification of novel …

Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells

KA Kang, MJ Piao, YJ Hyun, AX Zhen, SJ Cho… - … & Molecular Medicine, 2019 - nature.com
Luteolin, a dietary flavone, modulates various signaling pathways involved in
carcinogenesis. In this study, we investigated the molecular mechanism that underlies the …

Adapting and surviving: intra and extra-cellular remodeling in drug-resistant gastric cancer cells

S Russi, HK Verma, S Laurino, P Mazzone… - International journal of …, 2019 - mdpi.com
Despite the significant recent advances in clinical practice, gastric cancer (GC) represents a
leading cause of cancer-related deaths in the world. In fact, occurrence of chemo-resistance …

Epigenetic mechanisms in gastric cancer: potential new therapeutic opportunities

M Canale, A Casadei-Gardini, P Ulivi… - International Journal of …, 2020 - mdpi.com
Gastric cancer (GC) is one of the deadliest malignancies worldwide. Complex disease
heterogeneity, late diagnosis, and suboptimal therapies result in the poor prognosis of …

Gastric Cancer in the Era of Epigenetics

G Christodoulidis, KE Koumarelas, MN Kouliou… - International Journal of …, 2024 - mdpi.com
Gastric cancer (GC) remains a significant contributor to cancer-related mortality. Novel high-
throughput techniques have enlightened the epigenetic mechanisms governing gene …

DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells

W Sun, G Ma, L Zhang, P Wang, N Zhang, Z Wu… - Cell Death & …, 2021 - nature.com
ADAMTS9 belongs to the ADAMTS (a disintegrin and metalloproteinase with
thrombospondin motifs) protein family, and its expression is frequently silenced due to …

Interaction between DNMT3B and MYH11 via hypermethylation regulates gastric cancer progression

J Wang, P Xu, Y Hao, T Yu, L Liu, Y Song, Y Li - BMC cancer, 2021 - Springer
Background Gastric cancer (GC) has an unwelcoming prognosis when diagnosed at an
advanced stage. The purpose of this study was to examine the expression of myosin heavy …

Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: the link between signaling pathways and cancer

J Amani, N Gorjizadeh, S Younesi, M Najafi, AM Ashrafi… - DNA repair, 2021 - Elsevier
At the cellular level, DNA repair mechanisms are crucial in maintaining both genomic
integrity and stability. DNA damage appears to be a central culprit in tumor onset and …

Engineered biosensors for diagnosing multidrug resistance in microbial and malignant cells

NG Jha, DS Dkhar, SK Singh, SJ Malode, NP Shetti… - Biosensors, 2023 - mdpi.com
To curtail pathogens or tumors, antimicrobial or antineoplastic drugs have been developed.
These drugs target microbial/cancer growth and survival, thereby improving the host's …