Molecular mechanisms of antibiotic resistance revisited
EM Darby, E Trampari, P Siasat, MS Gaya… - Nature Reviews …, 2023 - nature.com
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …
Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria
RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …
A synthetic antibiotic class overcoming bacterial multidrug resistance
The dearth of new medicines effective against antibiotic-resistant bacteria presents a
growing global public health concern. For more than five decades, the search for new …
growing global public health concern. For more than five decades, the search for new …
Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR
N Obana, H Takada, C Crowe-McAuliffe… - Nucleic Acids …, 2023 - academic.oup.com
Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F
subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The …
subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The …
An overview of macrolide resistance in streptococci: prevalence, mobile elements and dynamics
D Berbel, A González-Díaz, G López de Egea… - Microorganisms, 2022 - mdpi.com
Streptococcal infections are usually treated with beta-lactam antibiotics, but, in case of
allergic patients or reduced antibiotic susceptibility, macrolides and fluoroquinolones are the …
allergic patients or reduced antibiotic susceptibility, macrolides and fluoroquinolones are the …
Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes
TO Koller, KJ Turnbull, K Vaitkevicius… - Nucleic Acids …, 2022 - academic.oup.com
HflX is a ubiquitous bacterial GTPase that splits and recycles stressed ribosomes. In addition
to HflX, Listeria monocytogenes contains a second HflX homolog, HflXr. Unlike HflX, HflXr …
to HflX, Listeria monocytogenes contains a second HflX homolog, HflXr. Unlike HflX, HflXr …
Structure of the translating Neurospora ribosome arrested by cycloheximide
Ribosomes translate RNA into proteins. The protein synthesis inhibitor cycloheximide (CHX)
is widely used to inhibit eukaryotic ribosomes engaged in translation elongation. However …
is widely used to inhibit eukaryotic ribosomes engaged in translation elongation. However …
Nanotechnology: a contemporary therapeutic approach in combating infections from multidrug-resistant bacteria
In the 20th century, the discovery of antibiotics played an essential role in the fight against
infectious diseases, including meningitis, typhoid fever, pneumonia and Mycobacterium …
infectious diseases, including meningitis, typhoid fever, pneumonia and Mycobacterium …
The ABCF proteins in Escherichia coli individually cope with 'hard-to-translate' nascent peptide sequences
Y Chadani, S Yamanouchi, E Uemura… - Nucleic Acids …, 2024 - academic.oup.com
Organisms possess a wide variety of proteins with diverse amino acid sequences, and their
synthesis relies on the ribosome. Empirical observations have led to the misconception that …
synthesis relies on the ribosome. Empirical observations have led to the misconception that …
Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics
C Crowe-McAuliffe, V Murina, KJ Turnbull… - Nature …, 2022 - nature.com
PoxtA and OptrA are ATP binding cassette (ABC) proteins of the F subtype (ABCF). They
confer resistance to oxazolidinone and phenicol antibiotics, such as linezolid and …
confer resistance to oxazolidinone and phenicol antibiotics, such as linezolid and …