In this study, we designed and synthesized a novel class of 1, 3, 4-oxadiazolyl-containing β-
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …

Abstract α-Glucosidase is an important therapeutic target of diabetes mellitus. To find potent
α-glucosidase inhibitors, thirty-one β-carboline derivatives containing piperazine moieties …

Carbolines are a prominent class of tricyclic alkaloids omnipresent in natural products and
bioactive compounds. Four different carboline regioisomers are known (α‐, β‐, γ‐, and δ …

Discovery of small molecule inhibitors targeting Mcl-1 (Myeloid cell leukemia 1) confronts
many challenges. Based on the fact that Mcl-1 is mainly localized in mitochondria, we …

Alzheimer's disease (AD) has few effective treatment options and continues to be a major
global health concern. AD is a neurodegenerative disease that typically affects elderly …

Developing and excavating new agrochemicals with highly active and safe is an important
tactic for protecting crop health and food safety. In this paper, to discover the new bactericide …

The comprehension of the kinetic processes involved in redox reactions with alkaloids such
as β-carbolines (βCs) is crucial to unveil differences in the reactivity of these substances. To …

In this work, a novel, green, and atom-efficient method for the synthesis of tetrahydro-β-
carboline derivatives using electrochemistry (EC) in deep eutectic solvents (DESs) was …

To explore the effect of the introduction of the amino and substituted amino groups on the
antitumor activity of harmine, twenty-five novel 6-amino substituted harmine derivatives (3a …

Azacarbazoles have attracted significant interest due to their valuable properties, such as
anti-pathogenic and antitumor activity. In this study, a series of structurally related tricyclic …