Genetic ancestry does not explain increased atopic dermatitis susceptibility or worse disease control among African American subjects in 2 large US cohorts

K Abuabara, Y You, DJ Margolis, TJ Hoffmann… - Journal of Allergy and …, 2020 - Elsevier
Background Atopic dermatitis (AD) is more common among African American children.
Whether there are racial/ethnic difference among adults with AD and the causes for those …

Multisite chronic pain as a causal risk factor for coronary artery disease: findings from Mendelian randomization

J Zhu, N Wang, H Liu, H Jiang, B Cai, D Chen, Y Li - Pain, 2023 - journals.lww.com
The potential consequences of the number of chronic pain sites (referred to multisite chronic
pain) on the risk of cardiovascular diseases (CVDs) remain unclear. We attempted to …

Leukocyte telomere length and sarcopenia-related traits: A bidirectional Mendelian randomization study

D Wang, C Li, X Zhang, Y Li, J He, X Guo - Plos one, 2024 - journals.plos.org
Accumulating evidence indicated that leukocyte telomere length (LTL) was related to
sarcopenia. However, it is still not clear whether the association of changes in LTL with …

[HTML][HTML] Synergizing mouse and human studies to understand the heterogeneity of obesity

P Gordon-Larsen, JE French, N Moustaid-Moussa… - Advances in …, 2021 - Elsevier
Obesity is routinely considered as a single disease state, which drives a “one-size-fits-all”
approach to treatment. We recently convened the first annual University of North Carolina …

Self-reported walking pace and risk of cardiovascular diseases: a two-sample mendelian randomization study

L Chen, X Sun, Y He, L Zheng - Frontiers in genetics, 2022 - frontiersin.org
Background: In observational studies, the self-reported walking pace has been associated
with the risk of cardiovascular diseases (CVD). However, whether those associations …

Genetics of obesity in East Asians

C Sun, P Kovacs, E Guiu-Jurado - Frontiers in Genetics, 2020 - frontiersin.org
Obesity has become a public health problem worldwide. Compared with Europe, people in
Asia tend to suffer from type 2 diabetes with a lower body mass index (BMI). Genome-wide …

Mice Lacking Gpr75 are Hypophagic and Thin

DR Powell, DD Doree, CM DaCosta… - … syndrome and obesity …, 2022 - Taylor & Francis
Purpose Humans with haploinsufficiency of GPR75, an orphan GPCR, are thin. Gpr75
knockout (KO) mice are also thin with improved glucose homeostasis. We wanted to confirm …

Technologies, strategies, and cautions when deconvoluting genome‐wide association signals: FTO in focus

MC Pahl, SFA Grant, RL Leibel… - Obesity …, 2023 - Wiley Online Library
Genome‐wide association studies have revealed a plethora of genetic variants that
correlate with polygenic conditions. However, causal molecular mechanisms have proven …

Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis

LB Vargas, LA Lange, K Ferrier, F Aguet… - International Journal of …, 2023 - nature.com
Background/objectives Obesity, defined as excessive fat accumulation that represents a
health risk, is increasing in adults and children, reaching global epidemic proportions. Body …

Cannabis use and the risk of cardiovascular diseases: a Mendelian randomization study

J Zhao, H Chen, C Zhuo, S Xia - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Several observational studies have shown that cannabis use has negative effects on the
cardiovascular system, but the causality of this relationship has not been confirmed. The aim …