Genetic ancestry does not explain increased atopic dermatitis susceptibility or worse disease control among African American subjects in 2 large US cohorts
Background Atopic dermatitis (AD) is more common among African American children.
Whether there are racial/ethnic difference among adults with AD and the causes for those …
Whether there are racial/ethnic difference among adults with AD and the causes for those …
Multisite chronic pain as a causal risk factor for coronary artery disease: findings from Mendelian randomization
J Zhu, N Wang, H Liu, H Jiang, B Cai, D Chen, Y Li - Pain, 2023 - journals.lww.com
The potential consequences of the number of chronic pain sites (referred to multisite chronic
pain) on the risk of cardiovascular diseases (CVDs) remain unclear. We attempted to …
pain) on the risk of cardiovascular diseases (CVDs) remain unclear. We attempted to …
Leukocyte telomere length and sarcopenia-related traits: A bidirectional Mendelian randomization study
D Wang, C Li, X Zhang, Y Li, J He, X Guo - Plos one, 2024 - journals.plos.org
Accumulating evidence indicated that leukocyte telomere length (LTL) was related to
sarcopenia. However, it is still not clear whether the association of changes in LTL with …
sarcopenia. However, it is still not clear whether the association of changes in LTL with …
[HTML][HTML] Synergizing mouse and human studies to understand the heterogeneity of obesity
Obesity is routinely considered as a single disease state, which drives a “one-size-fits-all”
approach to treatment. We recently convened the first annual University of North Carolina …
approach to treatment. We recently convened the first annual University of North Carolina …
Self-reported walking pace and risk of cardiovascular diseases: a two-sample mendelian randomization study
L Chen, X Sun, Y He, L Zheng - Frontiers in genetics, 2022 - frontiersin.org
Background: In observational studies, the self-reported walking pace has been associated
with the risk of cardiovascular diseases (CVD). However, whether those associations …
with the risk of cardiovascular diseases (CVD). However, whether those associations …
Genetics of obesity in East Asians
C Sun, P Kovacs, E Guiu-Jurado - Frontiers in Genetics, 2020 - frontiersin.org
Obesity has become a public health problem worldwide. Compared with Europe, people in
Asia tend to suffer from type 2 diabetes with a lower body mass index (BMI). Genome-wide …
Asia tend to suffer from type 2 diabetes with a lower body mass index (BMI). Genome-wide …
Mice Lacking Gpr75 are Hypophagic and Thin
DR Powell, DD Doree, CM DaCosta… - … syndrome and obesity …, 2022 - Taylor & Francis
Purpose Humans with haploinsufficiency of GPR75, an orphan GPCR, are thin. Gpr75
knockout (KO) mice are also thin with improved glucose homeostasis. We wanted to confirm …
knockout (KO) mice are also thin with improved glucose homeostasis. We wanted to confirm …
Technologies, strategies, and cautions when deconvoluting genome‐wide association signals: FTO in focus
Genome‐wide association studies have revealed a plethora of genetic variants that
correlate with polygenic conditions. However, causal molecular mechanisms have proven …
correlate with polygenic conditions. However, causal molecular mechanisms have proven …
Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis
Background/objectives Obesity, defined as excessive fat accumulation that represents a
health risk, is increasing in adults and children, reaching global epidemic proportions. Body …
health risk, is increasing in adults and children, reaching global epidemic proportions. Body …
Cannabis use and the risk of cardiovascular diseases: a Mendelian randomization study
J Zhao, H Chen, C Zhuo, S Xia - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Several observational studies have shown that cannabis use has negative effects on the
cardiovascular system, but the causality of this relationship has not been confirmed. The aim …
cardiovascular system, but the causality of this relationship has not been confirmed. The aim …