The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three
closely linked gene clusters (Pcdh α, Pcdh β, and Pcdh γ). Here, we show that all three gene …

In the mouse, olfactory sensory neurons (OSNs) expressing the same odorant receptor (OR)
converge their axons to a specific set of glomeruli in the olfactory bulb. To study how OR …

Proper brain wiring during development is pivotal for adult brain function. Neurons display a
high degree of polarization both morphologically and functionally, and this polarization …

Olfactory impairments contribute to the psychopathology of mental illnesses such as
schizophrenia and depression. Recent neuroscience research has shed light on the …

Synaptic activity regulates the postsynaptic accumulation of AMPA receptors over timescales
ranging from minutes to days. Indeed, the regulated trafficking and mobility of GluR1 AMPA …

The molecular mechanisms regulating olfactory receptor (OR) expression in the mammalian
nose are not yet understood. Here, we identify the transient expression of histone …

The monogenic and monoallelic expression of only one out of> 1000 mouse olfactory
receptor (ORs) genes requires the formation of large heterochromatic chromatin domains …

Olfactory sensory neurons (OSNs) convert the stochastic choice of one of> 1,000 olfactory
receptor (OR) genes into precise and stereotyped axon targeting of OR-specific glomeruli in …

Sensory processing in olfactory systems is organized across olfactory bulb glomeruli,
wherein axons of peripheral sensory neurons expressing the same olfactory receptor co …

In developing brains, activity-dependent remodeling facilitates the formation of precise
neuronal connectivity. Synaptic competition is known to facilitate synapse elimination; …