The adverse effects of mechanical ventilation in acute respiratory distress syndrome (ARDS)
arise from two main causes: unphysiological increases of transpulmonary pressure and …

Prone position (PP) has been used since the 1970s to treat severe hypoxemia in patients
with ARDS because of its effectiveness at improving gas exchange. Compared with the …

Ventilator-induced lung injury is a side-effect of mechanical ventilation. Its prevention or
attenuation implies knowledge of the sequence of events that lead from mechanical stress to …

The present authors hypothesised that in severe acute respiratory distress syndrome
(ARDS), pronation may reduce ventilator-induced overall stress (ie transpulmonary pressure …

In patients with acute respiratory distress syndrome (ARDS), in supine position, there is a
decrease of inflation along the sternum vertebral axis, up to lung collapse. In 1991 we …

Objective: To investigate if prone position delays the progression of experimental ventilator-
induced lung injury, possibly due to a more homogeneous distribution of strain within lung …

Background A lung-protecting strategy is essential when ventilating acute lung injury/acute
respiratory distress syndrome patients. Current emphasis is on limiting inspiratory pressure …

In patients with acute lung injury and acute respiratory distress syndrome, a protective
mechanical ventilation strategy characterized by low tidal volumes has been associated with …

Background Septic shock is often associated with acute respiratory distress syndrome, a
serious clinical problem exacerbated by improper mechanical ventilation. Ventilator-induced …

Background Mechanical ventilation worsens acute respiratory distress syndrome, but this
secondary “ventilator-associated” injury is variable and difficult to predict. The authors aimed …