Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

Novel immune checkpoint blockade with ipilimumab, an antibody blocking the cytotoxic T-
lymphocyte antigen 4 (CTLA4), is revolutionizing cancer therapy. However, ipilimumab …

Estrogens influence many physiological processes in mammals, including but not limited to
reproduction, cardiovascular health, bone integrity, cognition, and behavior. Given this …

17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …

Estrogen is an important sex steroid hormone which serves an important role in the
regulation of a number of biological functions, including regulating bone density, brain …

Although incidence of colorectal cancer (CRC) in the United States has declined in recent
years, rates remain higher in men than in women and the male‐to‐female incidence rate …

According to epidemiological studies, twice as many women as men are affected by irritable
bowel syndrome (IBS) in western countries, suggesting a role for sex hormones in IBS …

Lignans are present in a wide range of foods consumed daily in the Western world such as
flaxseed and other seeds, as well as vegetables, fruits and beverages such as coffee, tea …

Tumor suppressor p53 maintains genome stability by regulating diverse cellular functions
including cell cycle arrest, apoptosis, senescence and metabolic homeostasis. Mutations in …