Glaucoma causes loss of vision through degeneration of the retinal ganglion cell (RGC)
projection to the brain. The disease is characterized by sensitivity to intraocular pressure …

Extracellular tissue fluids are interesting biomatrices that have recently attracted scientists'
interest. Many significant biomarkers for localized external organ diseases have been …

Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand
challenge in glaucoma care. Here we introduce a class of smart soft contact lenses …

Many neurodegenerative diseases cause degeneration of specific types of neurons. For
example, glaucoma leads to death of retinal ganglion cells, leaving other neurons intact …

Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic
targets based on neuronal protection, repair, or regeneration, independent of etiology or site …

With the identification of novel targets, the number of interventional clinical trials in
ophthalmology has increased. Visual acuity has for a long time been considered the gold …

Highlights•An aptamer with high affinity, high specificity, and high stability for binding to both
human-derived and rat-derived GDF15 was obtained.• The molecular mechanism and key …

Background Neurological and ophthalmological neurodegenerative diseases in large part
share underlying biology and pathophysiology. Despite extensive preclinical research on …

Abstract DARC (Detection of Apoptosing Retinal Cells) is a retinal imaging technology that
has been developed within the last 2 decades from basic laboratory science to Phase 2 …

Vitreous cortex hyalocytes are resident macrophage cells that help maintain the
transparency of the media, provide immunosurveillance, and respond to tissue injury and …