Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Abstract Ischemia/reperfusion (I/R) is a pathological process that occurs in numerous organs
throughout the human body, and it is frequently associated with severe cellular damage and …

Ischemic stroke represents a significant danger to human beings, especially the elderly.
Interventions are only available to remove the clot, and the mechanism of neuronal death …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Legumain is required for maintenance of normal kidney homeostasis. However, its role in
acute kidney injury (AKI) is still unclear. Here, we induced AKI by bilateral ischemia …

Regulated necrosis has been reported to exert an important role in the pathogenesis of
various diseases, including renal ischemia-reperfusion (I/R) injury. Damage to renal tubular …

Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem
without effective therapy and is a significant and frequent cause of morbidity and mortality …

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However,
the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in …

Ferroptosis is a newly discovered form of non-apoptotic regulated cell death and is
characterized by iron-dependent and lipid peroxidation. Due to the enhanced dependence …

Ferroptosis is an iron-dependent regulated necrosis. This study aims to evaluate the
contribution of ferroptosis to ischemia or reperfusion injury, and lay a basis for precise …