Collaborations of physicians and researchers with industry can provide valuable benefits to
society, particularly in the translation of basic scientific discoveries to new therapies and …

The knowledge-to-action cycle represents a frame-work for the implementation of
knowledge. 1 As discussed in the first article in this series, the action phases of this cycle …

Healthcare decision making is complex. Decision-making processes and the factors
(criteria) that decision makers should consider vary for different types of decisions, including …

Objectives To identify factors associated with the implementability of clinical practice
guidelines (CPGs) and to determine what characteristics improve their uptake. Study Design …

Background Developing and updating high-quality guidelines requires substantial time and
resources. To reduce duplication of effort and enhance efficiency, we developed a process …

Background Clinical practice guidelines are largely conceived as tools that will inform health
professionals' decisions rather than foster patient involvement in decision making. The time …

Since the emergence of the Evidence-Based Medicine (EBM) movement, the nature and
role of evidence in medicine has been much debated. The formal classification of evidence …

Evidence-based guidelines whether national, regional or developed by specialty groups,
must search for, and explicitly consider, evidence from sources other than conventional …

Medication nonadherence is a major obstacle to translating treatment efficacy from research
settings into effectiveness in clinical practice for patients with affective disorders. Adherence …

Objectives The aim of this paper is to provide detailed guidance on how to incorporate
health equity within the GRADE (Grading Recommendations Assessment and Development …