Several studies implicate dysregulation of the ADAMTS-13/VWF axis as playing a major role
in vaso-occlusive events (VOE) in SCD. Another highlight is reducing iron overload, which …

Complement factor D (FD) is a serine protease present predominantly in the active form in
circulation. It is synthesized as a zymogen (pro-FD), but it is continuously converted to FD by …

Abstract Sickle Cell Disease (SCD) is a hereditary blood disorder characterized by the
presence of abnormal hemoglobin, leading to the formation of sickle-shaped red blood cells …

Introduction Overactivation of the lectin pathway of complement plays a pathogenic role in a
broad range of immune-mediated and inflammatory disorders; mannan-binding lectin …

A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and
stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor …

The lectin pathway (LP) of complement mediates inflammatory processes linked to tissue
damage and loss of function following traumatic brain injury (TBI). LP activation triggers a …

Vaso-occlusive pain episodes (VOE) cause severe pain in patients with sickle cell disease
(SCD). Vaso-occlusive events promote ischemia/reperfusion pathobiology that activates …

Mannose-binding lectin-associated serine protease (MASP) is a type of central serine
protease in the complement lectin pathway. In the present study, a MASP-like was identified …

Aberrant coagulation in sickle cell disease (SCD) is linked to extracellular vesicle (EV)
exposure. However, there is no consensus on the contributions of small EVs (SEVs) and …

Sickle cell disease (SCD) is an inherited hemoglobinopathy with protean clinical
manifestations. The liver could be affected by various SCD-associated complications of an …