Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
A Mushtaq, U Azam, S Mehreen, MM Naseer - European journal of …, 2023 - Elsevier
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
[HTML][HTML] Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
Recent developments in synthetic α-glucosidase inhibitors: A comprehensive review with structural and molecular insight
Diabetes mellitus is the prominent metabolic disorder affecting 422 million people around
the globe and cause severe associated problems like kidney disorders, heart and nervous …
the globe and cause severe associated problems like kidney disorders, heart and nervous …
Synthesis of Novel 2,3-Dihydro-1,5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies
R Mehmood, EU Mughal, EB Elkaeed, RJ Obaid… - ACS …, 2022 - ACS Publications
In the present study, a series of 2, 3-dihydro-1, 5-benzothiazepine derivatives 1B–14B has
been synthesized sand characterized by various spectroscopic techniques. The enzyme …
been synthesized sand characterized by various spectroscopic techniques. The enzyme …
Synthesis and evaluation of 1, 3, 5-triaryl-2-pyrazoline derivatives as potent dual inhibitors of urease and α-glucosidase together with their cytotoxic, molecular …
In the present work, a concise library of 1, 3, 5-triaryl-2-pyrazolines (2a–2q) was designed
and synthesized by employing a multistep strategy, and the newly synthesized compounds …
and synthesized by employing a multistep strategy, and the newly synthesized compounds …
Exploring biological efficacy of novel benzothiazole linked 2, 5-disubstituted-1, 3, 4-oxadiazole hybrids as efficient α-amylase inhibitors: Synthesis, characterization …
In an effort to explore a class of novel antidiabetic agents, we have made an effort to
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
Theoretical vibrational spectroscopy (FT-IR), PED and DFT calculations of chromones and thiochromones
Chromones are heterocyclic compounds having a benzoannelated γ-pyrone ring and
recognized as privileged structures and useful templates for the design of novel compounds …
recognized as privileged structures and useful templates for the design of novel compounds …
Discovery of triazole tethered thymol/carvacrol-coumarin hybrids as new class of α-glucosidase inhibitors with potent in vivo antihyperglycemic activities
Keeping in view the inhibitory potential of monoterpenes thymol and carvacrol as well as
coumarin nucleus against α-glucosidase, novel series of thymol/carvacrol-coumarin hybrids …
coumarin nucleus against α-glucosidase, novel series of thymol/carvacrol-coumarin hybrids …
Discovery of chalcone derivatives as potential α-glucosidase and cholinesterase inhibitors: Effect of hyperglycemia in paving a path to dementia
HA Al-ghulikah, EU Mughal, EB Elkaeed… - Journal of Molecular …, 2023 - Elsevier
In the present study, a series of fascinating chalcone derivatives 1C-14C has been designed
and synthesized by Claisen-Schmidt condensation. The target compounds were screened …
and synthesized by Claisen-Schmidt condensation. The target compounds were screened …
Flavone-based hydrazones as new tyrosinase inhibitors: Synthetic imines with emerging biological potential, SAR, molecular docking and drug-likeness studies
Targeting tyrosinase (TYR), a key enzyme responsible for melanogenesis disorders, is a
well-known approach utilized for the development of melanogenesis inhibitor. A variety of …
well-known approach utilized for the development of melanogenesis inhibitor. A variety of …