[HTML][HTML] Implications of glial nitric oxide in neurodegenerative diseases

JE Yuste, E Tarragon, CM Campuzano… - Frontiers in cellular …, 2015 - frontiersin.org
Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases
(NOS) which plays a critical role in a number of physiological and pathological processes in …

Oxidative stress and neurodegeneration: where are we now?

B Halliwell - Journal of neurochemistry, 2006 - Wiley Online Library
The brain and nervous system are prone to oxidative stress, and are inadequately equipped
with antioxidant defense systems to prevent 'ongoing'oxidative damage, let alone the extra …

Concepts of neural nitric oxide‐mediated transmission

J Garthwaite - European Journal of Neuroscience, 2008 - Wiley Online Library
As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still
thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the …

Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application

MJ Millan - Pharmacology & therapeutics, 2006 - Elsevier
Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

[HTML][HTML] Resveratrol protects rats from Aβ-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation

TC Huang, KT Lu, YYP Wo, YJ Wu, YL Yang - PloS one, 2011 - journals.plos.org
Alzheimer disease (AD) is an age-dependent neurodegenerative disease characterized by
the formation of β–amyloid (Aβ)-containing senile plaque. The disease could be induced by …

Curcumin loaded solid lipid nanoparticles: an efficient formulation approach for cerebral ischemic reperfusion injury in rats

V Kakkar, SK Muppu, K Chopra, IP Kaur - European Journal of …, 2013 - Elsevier
Scope To evaluate curcumin loaded solid lipid nanoparticles (C-SLNs) in the experimental
paradigm of cerebral ischemia (BCCAO model) in rats. Methods and results Oral …

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase

ED Garcin, AS Arvai, RJ Rosenfeld, MD Kroeger… - Nature chemical …, 2008 - nature.com
Nitric oxide synthase (NOS) enzymes synthesize nitric oxide, a signal for vasodilatation and
neurotransmission at low concentrations and a defensive cytotoxin at higher concentrations …

[HTML][HTML] Why is nitric oxide important for our brain?

E Džoljić, I Grabatinić, V Kostić - Functional neurology, 2015 - ncbi.nlm.nih.gov
Why is nitric oxide important for our brain? - PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation …

Nitric oxide and nitroxidative stress in Alzheimer's disease

T Malinski - Journal of Alzheimer's disease, 2007 - content.iospress.com
Nitric oxide is a signaling molecule produced by neurons and endothelial cells in the brain.
NO is synthesized from L-arginine and oxygen by nitric oxide synthase: neuronal (nNOS) …

NO, CO and H2S: A trinacrium of bioactive gases in the brain

R Siracusa, VA Voltarelli, AT Salinaro… - Biochemical …, 2022 - Elsevier
Oxygen and carbon dioxide are time honored gases that have direct bearing on almost all
life forms, but over the past thirty years, and in large part due to the Nobel Prize Award in …