Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and
immunosuppressive therapeutics in the 1940s and their continued use and development …

The past decade has seen several critical advances in our understanding of hypothalamic–
pituitary–adrenal (HPA) axis regulation. Homeostatic physiological circuits need to integrate …

Despite various approaches to immunoassay and chromatography for monitoring cortisol
concentrations, conventional methods require bulky external equipment, which limits their …

Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and
excessive secretion of cortisol. The syndrome is associated with increased mortality and …

Abstract Cushing's disease (CD), or pituitary-dependent Cushing's syndrome, is a severe
endocrine disease caused by a corticotroph pituitary tumor and associated with increased …

Chronic exposure to excess glucorticoids results in diverse manifestations of Cushing's
syndrome, including debilitating morbidities and increased mortality. Genetic and molecular …

It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

Secondary hypertension refers to arterial hypertension due to an identifiable cause and
affects∼ 5–10% of the general hypertensive population. Because secondary forms are rare …

Recommendations about therapy for hypertension are here preceded by some
considerations on the strength of available evidence on the benefits associated with …

Cushing's syndrome is a rare disorder resulting from prolonged exposure to excess
glucocorticoids. Early diagnosis and treatment of Cushing's syndrome is associated with a …