Ovarian age is classically considered the main cause of female reproductive infertility. In
women, the process proceeds as an ongoing decline in the primordial follicle stockpile and it …

Reproductive aging is a natural process conserved across species and is well-known in
females. It shows age-related follicle depletion and reduction of oocyte quality, eventually …

Early embryonic arrest and fragmentation (EEAF) is a common phenomenon leading to
female infertility, but the genetic determinants remain largely unknown. The Moloney …

One of the most critical issues to be solved in reproductive medicine is the treatment of
patients with multiple failures of assisted reproductive treatment caused by low-quality …

Maternal ageing is one of the major causes of reduced ovarian reserve and low oocyte
quality in elderly women. Decreased oocyte quality is the main cause of age‐related …

Oocytes may carry mutations in their mitochondrial DNA (mtDNA) which affect fertility and
embryo development leading to hereditary diseases or rejection. Mitochondrial replacement …

Background The reportedly high mutation rate of mitochondrial DNA (mtDNA) may be
attributed to the absence of histone protection and complete repair mechanisms …

Although it is not a well-established technology, oocyte cryopreservation is becoming
prevalent in assisted reproductive technologies in response to the growing demands of …

C‐natriuretic peptide (CNP) is the central regulator of oocyte meiosis progression, thus
coordinating synchronization of oocyte nuclear‐cytoplasmic maturation. However, whether …

Organ aging is at the core of the disease of aging and drives the occurrence and
development of a variety of illnesses, such as Alzheimer's, cardiovascular disease, and …