Retinal microglia: Functions and diseases
W Fan, W Huang, J Chen, N Li, L Mao, S Hou - Immunology, 2022 - Wiley Online Library
Microglia, the resident immune cells in the retina and nervous system, make irreplaceable
contributions to the maintenance of normal homeostasis and immune surveillance of these …
contributions to the maintenance of normal homeostasis and immune surveillance of these …
[HTML][HTML] More than meets the eye: The role of microglia in healthy and diseased retina
E Murenu, MJ Gerhardt, M Biel… - Frontiers in …, 2022 - frontiersin.org
Microglia are the main resident immune cells of the nervous system and as such they are
involved in multiple roles ranging from tissue homeostasis to response to insults and circuit …
involved in multiple roles ranging from tissue homeostasis to response to insults and circuit …
[HTML][HTML] Mesenchymal stem cell-based therapy for retinal degenerative diseases: experimental models and clinical trials
V Holan, K Palacka, B Hermankova - Cells, 2021 - mdpi.com
Retinal degenerative diseases, such as age-related macular degeneration, retinitis
pigmentosa, diabetic retinopathy or glaucoma, represent the main causes of a decreased …
pigmentosa, diabetic retinopathy or glaucoma, represent the main causes of a decreased …
[HTML][HTML] Microglia: The breakthrough to treat neovascularization and repair blood-retinal barrier in retinopathy
X Fu, S Feng, H Qin, L Yan, C Zheng… - Frontiers in Molecular …, 2023 - frontiersin.org
Microglia are the primary resident retinal macrophages that monitor neuronal activity in real-
time and facilitate angiogenesis during retinal development. In certain retinal diseases, the …
time and facilitate angiogenesis during retinal development. In certain retinal diseases, the …
[HTML][HTML] Characterization of macrophage-like cells in retinal vein occlusion using en face optical coherence tomography
Y Zeng, X Zhang, L Mi, Y Gan, Y Su, M Li… - Frontiers in …, 2022 - frontiersin.org
Purpose To investigate the clinical features of a macrophage-like cell (MLC) obtained by en
face optical coherence tomography (OCT) in retinal vein occlusion (RVO). Methods The …
face optical coherence tomography (OCT) in retinal vein occlusion (RVO). Methods The …
[HTML][HTML] Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of …
A Bedolla, A Taranov, F Luo, J Wang, F Turcato… - Journal of …, 2022 - Springer
Background Two recently developed novel rodent models have been reported to ablate
microglia, either by genetically targeting microglia (via Cx3cr1-creER: iDTR+ Dtx) or through …
microglia, either by genetically targeting microglia (via Cx3cr1-creER: iDTR+ Dtx) or through …
[HTML][HTML] Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
MI Avrutsky, CC Ortiz, KV Johnson, AM Potenski… - Nature …, 2020 - nature.com
Central nervous system ischemic injury features neuronal dysfunction, inflammation and
breakdown of vascular integrity. Here we show that activation of endothelial caspase-9 after …
breakdown of vascular integrity. Here we show that activation of endothelial caspase-9 after …
[HTML][HTML] Therapeutic targeting of retinal immune microenvironment with CSF-1 receptor antibody promotes visual function recovery after ischemic optic neuropathy
Retinal ischemia/reperfusion injury (RI) is a common cause of irreversible visual impairment
and blindness in elderly and critical unmet medical need. While no effective treatment is …
and blindness in elderly and critical unmet medical need. While no effective treatment is …
[HTML][HTML] Distinguished functions of microglia in the two stages of oxygen-induced retinopathy: a novel target in the treatment of ischemic retinopathy
Z Zhou, Y Jing, Y Niu, T Chang, J Sun, C Guo, Y Wang… - Life, 2022 - mdpi.com
Microglia is the resident immune cell in the retina, playing the role of immune surveillance in
a traditional concept. With the heated focus on the mechanisms of microglia in pathological …
a traditional concept. With the heated focus on the mechanisms of microglia in pathological …
[HTML][HTML] Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline
C Colón Ortiz, AM Neal, MI Avrutsky, M Choi… - Cell Death & …, 2022 - nature.com
Retinal neurovascular injuries are a leading cause of vision loss in young adults presenting
unmet therapeutic needs. Neurovascular injuries damage homeostatic communication …
unmet therapeutic needs. Neurovascular injuries damage homeostatic communication …