Possible involvement of the α1 isoform of 5′ AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle

T Toyoda, T Hayashi, L Miyamoto… - American Journal …, 2004 - journals.physiology.org
Recent studies have suggested that 5′ AMP-activated protein kinase (AMPK) is activated in
response to metabolic stresses, such as contraction, hypoxia, and the inhibition of oxidative …

AMP‐activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle

J Brandauer, SG Vienberg, MA Andersen… - The Journal of …, 2013 - Wiley Online Library
Key points• NAD is a substrate for sirtuins (SIRTs), which regulate gene transcription in
response to specific metabolic stresses.• Nicotinamide phosphoribosyl transferase (Nampt) …

Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms.

SL McGee, M Hargreaves - Clinical & Experimental …, 2006 - search.ebscohost.com
Skeletal muscle is a highly plastic tissue that has a remarkable ability to adapt to external
demands, such as exercise. Many of these adaptations can be explained by changes in …

Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase

N Kazgan, T Williams, LJ Forsberg… - Molecular biology of the …, 2010 - Am Soc Cell Biol
The metabolic regulator AMP-activated protein kinase (AMPK) maintains cellular
homeostasis through regulation of proteins involved in energy-producing and-consuming …

Exercise and the treatment of diabetes and obesity

DJ O'Gorman, A Krook - Medical Clinics of North America, 2011 - Elsevier
Lifestyle intervention programs encompassing exercise and healthy diets are an option for
the treatment and management of obesity and type 2 diabetes and have long been known to …

[HTML][HTML] Insight on transcriptional regulation of the energy sensing AMPK and biosynthetic mTOR pathway genes

A Sukumaran, K Choi, B Dasgupta - Frontiers in Cell and …, 2020 - frontiersin.org
The Adenosine Monophosphate-activated Protein Kinase (AMPK) and the Mechanistic
Target of Rapamycin (mTOR) are two evolutionarily conserved kinases that together …

Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes

AE Civitarese, MKC Hesselink… - American Journal …, 2005 - journals.physiology.org
Ingestion of carbohydrate during exercise may blunt the stimulation of fat oxidative pathways
by raising plasma insulin and glucose concentrations and lowering plasma free fatty acid …

A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer

AS Khan, DE Frigo - Nature Reviews Urology, 2017 - nature.com
Abstract The 5′-AMP-activated protein kinase (AMPK) is a master regulator of cellular
homeostasis. Despite AMPK's known function in physiology, its role in pathological …

Reduced glycogen availability is associated with increased AMPKα2 activity, nuclear AMPKα2 protein abundance, and GLUT4 mRNA expression in contracting …

GR Steinberg, MJ Watt, SL McGee… - Applied Physiology …, 2006 - cdnsciencepub.com
La disponibilité du glycogène peut influencer par des mécanismes non encore connus
l'expression de GLUT4 («glucose transporter 4») dans le muscle squelettique. La protéine …

AMP activated protein kinase: A next generation target for total metabolic control: Oncologic, Endocrine & Metabolic

P Misra - Expert opinion on therapeutic targets, 2008 - Taylor & Francis
Metabolic syndrome is characterized by a cluster of metabolic disorders, such as reduced
glucose tolerance, hyperinsulinemia, hypertension, visceral obesity and lipid disorders. The …