Personalized medicine (PM) is defined as “a form of medicine that uses information about a
person's genes, proteins, and environment to prevent, diagnose, and treat disease.” The …

Automation for genotyping of single nucleotide polymorphisms (SNPs) can be split into the
automation of the sample preparation and the automation of the analysis technology. SNP …

Generating human single-nucleotide polymorphisms (SNPs) is no longer a rate-limiting step
for genetic studies of disease. The number of SNPs in public databases already exceeds …

Speciation is the combination of evolutionary processes that leads to the reproductive
isolation of different populations. We investigate the significance of sex-chromosome …

Background: Enzymatic breakdown of the extracellular matrix, and possibly local
inflammation, contributes to intervertebral disc degeneration. We investigated whether …

Successful use and reliability of microarray technology is highly dependent on several
factors, including surface chemistry parameters and accessibility of cDNA targets to the DNA …

Single nucleotide polymorphism (SNP) genotyping is playing an increasing role in genome
mapping, pharmacogenetic studies, and drug discovery. To date, genome-wide scans and …

Successful investigation of common diseases requires advances in our understanding of the
organization of the genome. Linkage disequilibrium provides a theoretical basis for …

Background High-throughput genotyping of single nucleotide polymorphisms (SNPs)
generates large amounts of data. In many SNP genotyping assays, the genotype …

Most current single nucleotide polymorphism (SNP) genotyping methods are still too slow
and expensive for routine use in large association studies with hundreds or more SNPs in a …