The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and
progression of various cancers. CCL2 can activate tumour cell growth and proliferation …

Chronic pain is a maladaptive condition affecting 7%− 10% of the population worldwide and
can be accompanied by depression, anxiety, and insomnia. In particular, chronic pain is …

Aim Our previous study revealed that the C‐C motif chemokine receptor 2 (CCR2) is a
promising target for periodontitis prevention and treatment. However, CCR2 is a receptor …

Postsynaptic NMDARs at spinal synapses are required for postsynaptic long-term
potentiation and chronic pain. However, how presynaptic NMDARs (PreNMDARs) in spinal …

The communication between calcitonin gene-related peptide (CGRP) and cytokines plays a
prominent role in maintaining trigeminal ganglion (TG) and trigeminovascular sensitization …

Central post-stroke pain (CPSP) is a highly refractory form of central neuropathic pain that
has been poorly studied mechanistically. Recent observations have emphasized the critical …

Chronic pain remains a public health problem and contributes to the ongoing opioid
epidemic. Current pain management therapies still leave many patients with poorly …

Objective Repulsive guidance molecule‐a (RGMa) is a glycosylphosphatidylinositol‐linked
glycoprotein which has multiple functions including axon growth inhibition and immune …

The CC motif chemokine ligand 2 (CCL2) has been implicated in chronic pain, but its exact
mechanism of peripheral sensitization is unknown. In this study, we aimed to clarify the …

Immune cells play numerous roles in the host defense against the invasion of
microorganisms and pathogens, which induces the release of inflammatory mediators (eg …