Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …

Aging is an inevitable natural process that impacts every individual, and understanding its
effect on the gut microbiome and dendritic cell (DC) functionality in elderly subjects is …

The geroscience hypothesis proposes that addressing the biology of aging could directly
prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the …

Accumulation of senescent cells in organs and tissues is a hallmark of aging and known to
contribute to age-related diseases. Although aging-associated immune dysfunction, or …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …

Cigarette smoke (CS) poses a significant risk factor for respiratory, vascular, and organ
diseases owing to its high content of harmful chemicals and reactive oxygen species (ROS) …

Background Neutrophils and lymphocytes represent the larger percentage of all white blood
cells, they vary with age, with a progressive increase of the ratio in the first years of life, and …

Mitochondrial dysfunction is a hallmark of aging that contributes to inflammaging. It is
characterized by alterations of the mitochondrial DNA, reduced respiratory capacity …

Aging is characterized by an alteration of several physiological processes and biological
pathways that leads to an increased susceptibility to age-related diseases and death …