The blood–brain barrier: structure, regulation, and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal Transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Improving the efficacy of anti-EGFR drugs in GBM: Where we are going?

M Ge, Y Zhu, M Wei, H Piao, M He - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
The therapies targeting mutations of driver genes in cancer have advanced into clinical trials
for a variety of tumors. In glioblastoma (GBM), epidermal growth factor receptor (EGFR) is …

Exosomes; multifaceted nanoplatform for targeting brain cancers

N Mardi, F Salahpour-Anarjan, M Nemati, NS Baher… - Cancer letters, 2023 - Elsevier
At the moment, anaplastic changes within the brain are challenging due to the complexity of
neural tissue, leading to the inefficiency of therapeutic protocols. The existence of a cellular …

Study on the Role of an Erythrocyte Membrane‐Coated Nanotheranostic System in Targeted Immune Regulation of Alzheimer's Disease

Y Su, Y Huang, Q Kou, L Lu, H Jiang, X Li… - Advanced …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in the
elderly population. Despite significant advances in studies of the pathobiology on AD, there …

Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer's Disease Management

S Dighe, S Jog, M Momin, S Sawarkar, A Omri - Pharmaceutics, 2023 - mdpi.com
Alzheimer's disease, a progressive neurodegenerative condition, is characterized by a
gradual decline in cognitive functions. Current treatment approaches primarily involve the …

The Promise of Molecular Imaging: Focus on Central Nervous System Infections

S Shah, ML Turner, X Chen, BM Ances… - The Journal of …, 2023 - academic.oup.com
Central nervous system (CNS) infections can lead to high mortality and severe morbidity.
Diagnosis, monitoring, and assessing response to therapy of CNS infections is particularly …

Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges

JS Tan, MNB Jaffar Ali, BK Gan… - Expert Opinion on Drug …, 2023 - Taylor & Francis
ABSTRACT Introduction Viral nanoparticles (VNPs) are virus-based nanocarriers that have
been studied extensively and intensively for biomedical applications. However, their clinical …

[HTML][HTML] Development of computational intelligence models for assessment of drug nanonization using green chemistry technique: Improvement of drug solubility

B Huwaimel, TN Alharby - Case Studies in Thermal Engineering, 2023 - Elsevier
Determination of solubility via theoretical approaches was carried out in this study. Because
of its importance to the expansion of the pharmaceutical industry, this study models …

The inverse electron demand Diels–Alder cycloaddition with carbon‐11 and fluorine‐18: A gateway to pretargeted imaging across the blood–brain barrier

SH Zientek, S Thompson, SM Sephton… - Journal of Labelled …, 2023 - Wiley Online Library
There is increased focus on developing tools to image large biomolecules, such as
antibodies, within the brain using positron emission tomography (PET). The inverse electron …

A Scoping Review of Focused Ultrasound Enhanced Drug Delivery for Across the Blood–Brain Barrier for Brain Tumors

CM Young, A Viña-González… - Operative …, 2022 - journals.lww.com
METHODS: A review of current literature was conducted through a MEDLINE search
inclusive of articles on FUS, BBB, and brain tumor barrier, including human, modeling, and …