Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal
level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter …

Fentanyl is a powerful opioid anesthetic and analgesic, the use of which has caused an
increasing public health threat in the United States and elsewhere. Fentanyl was initially …

In this experimental randomized placebo-controlled 4-way crossover trial, we explored the
analgesic effects of inhaled pharmaceutical-grade cannabis in 20 chronic pain patients with …

Buprenorphine is a Schedule III opioid analgesic with unique pharmacodynamic and
pharmacokinetic properties that may be preferable to those of Schedule II full μ-opioid …

Background Opioids are potent painkillers but come with serious adverse effects ranging
from addiction to potentially lethal respiratory depression. A variety of drugs with separate …

The analgesic utility of opioid-based drugs is limited by the life-threatening risk of respiratory
depression. Opioid-induced respiratory depression (OIRD), mediated by the m-opioid …

The opioid overdose death toll in the United States is an ongoing public health crisis. We
characterized the magnitude and duration of respiratory depression, the leading cause of …

Background Opioid-induced respiratory depression driven by ligand binding to mu-opioid
receptors is a leading cause of opioid-related fatalities. Buprenorphine, a partial agonist …

Respiratory depression is common in patients recovering from surgery and anaesthesia.
Failure to recognise and lack of timely institution of intervention can lead to catastrophic …

Opioid-induced respiratory depression (OIRD) causes death following an opioid overdose,
yet the neurobiological mechanisms of this process are not well understood. Here, we show …