During space missions, astronauts are faced with a variety of challenges that are unique to
spaceflight and that have been known to cause physiological changes in humans over a …

Biofilm formation is an important virulence factor for the opportunistic microorganisms that
elicit skin infections. The recalcitrant feature of biofilms and their antibiotic tolerance impose …

During inflammation, the skin deploys antimicrobial peptides (AMPs) yet during allergic
inflammation it becomes more susceptible to Staphylococcus aureus. To understand this …

Background Atopic dermatitis (AD) is characterized by microbial dysbiosis, immune
dysregulation, and an impaired skin barrier. Microbial dysbiosis in AD involves a reduction …

Our skin has a unique barrier function, which is imperative for the body's protection against
external pathogens and environmental insults. Although interacting closely and sharing …

Background Atopic dermatitis (AD) is a heterogeneous, chronic inflammatory skin disease
linked to skin microbiome dysbiosis with reduced bacterial diversity and elevated relative …

Early life is a dynamic period for skin microbial colonization and immune development. We
postulate that microbial exposures in this period durably alter the skin immune trajectory and …

Our skin is the interface through which we mediate lifelong interactions with our surrounding
environment. Initial development of the skin's epidermis, adnexal structures, and barrier …

Background In recent decades, dramatic changes in modern environmental exposures and
lifestyles have resulted in a steep rise in the prevalence of allergic diseases such as asthma …

Staphylococcus aureus is a key pathogen in atopic dermatitis (AD) pathogenicity. Over half
of AD patients are carriers of S. aureus. Clinical isolates derived from AD patients produce …