B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

The endocrine pancreas represents an interesting arena for regenerative medicine and cell
therapeutics. One of the major pancreatic diseases, diabetes mellitus is a metabolic disorder …

The intrahepatic milieu is inhospitable to intraportal islet allografts,–, limiting their
applicability for the treatment of type 1 diabetes. Although the subcutaneous space …

Background B cells produce alloantibodies and activate alloreactive T cells, negatively
affecting kidney transplant survival. By contrast, regulatory B cells are associated with …

Background B cells play an important role in renal allograft pathology, particularly in acute
and chronic antibody-mediated rejection (AMR). B-cell activating factor belonging to the …

There has been increasing interest in the role played by B cells and their associated
antibody in the immune response to an allograft, driven by the need to undertake antibody …

During the past 5 decades, short‐term outcomes in kidney transplant have significantly
improved, in large part due to reduced rates and severity of acute rejection. Development of …

Donor-reactive memory T cells undermine organ transplant survival and are poorly
controlled by immunosuppression or costimulatory blockade. Memory CD4 T cells provide …

Much progress has been made toward understanding the mechanistic basis of
transplantation tolerance in experimental models, which implicates clonal deletion of …

Induction of tolerance remains a major goal in transplantation. Indeed, despite potent
immunosuppression, chronic rejection is still a real problem in transplantation. The humoral …