Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry: A review

NAAL Zahrani, RM El-Shishtawy, AM Asiri - European journal of medicinal …, 2020 - Elsevier
The leading cause of several degenerative diseases such as atherosclerosis, cancer, aging,
cardiovascular, and inflammatory diseases is oxidative stress, a consequence of …

Recent advances on the improvement of quercetin bioavailability

K Kandemir, M Tomas, DJ McClements… - Trends in Food Science & …, 2022 - Elsevier
Background Natural antioxidants, such as polyphenols, are finding increasing application in
functional foods designed to improve human health, wellbeing, and performance. Quercetin …

Structure-antioxidant activity relationship of methoxy, phenolic hydroxyl, and carboxylic acid groups of phenolic acids

J Chen, J Yang, L Ma, J Li, N Shahzad, CK Kim - Scientific reports, 2020 - nature.com
The antioxidant activities of 18 typical phenolic acids were investigated using 2, 2′-
diphenyl-1-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) assays …

Potential clinical benefits of quercetin in the early stage of COVID-19: results of a second, pilot, randomized, controlled and open-label clinical trial

F Di Pierro, S Iqtadar, A Khan… - … journal of general …, 2021 - Taylor & Francis
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
cause of the ongoing global pandemic known as COVID-19. Based on the potential antiviral …

Bioactivity of dietary polyphenols: The role of metabolites

SV Luca, I Macovei, A Bujor, A Miron… - Critical reviews in …, 2020 - Taylor & Francis
A polyphenol-rich diet protects against chronic pathologies by modulating numerous
physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation …

Possible therapeutic effects of adjuvant quercetin supplementation against early-stage COVID-19 infection: a prospective, randomized, controlled, and open-label …

F Di Pierro, G Derosa, P Maffioli… - … journal of general …, 2021 - Taylor & Francis
Background Quercetin, a well-known naturally occurring polyphenol, has recently been
shown by molecular docking, in vitro and in vivo studies to be a possible anti-COVID-19 …

Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases

SM Lagoumtzi, N Chondrogianni - Free Radical Biology and Medicine, 2021 - Elsevier
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …

Soy protein isolate-catechin non-covalent and covalent complexes: Focus on structure, aggregation, stability and in vitro digestion characteristics

S Dai, P Liao, Y Wang, T Tian, X Tong, B Lyu… - Food …, 2023 - Elsevier
Studies on soybean protein–polyphenol complexes mainly focus on the effects of non-
covalent/covalent interactions on the structure and function of the complexes, and there are …

Antioxidant and anti-inflammatory activities of quercetin and its derivatives

M Lesjak, I Beara, N Simin, D Pintać, T Majkić… - Journal of Functional …, 2018 - Elsevier
Quercetin is hardly bioavailable and largely transformed to different metabolites. Although
little is known about their biological activities, these metabolites are crucial for explanation of …

Advances in micro and nano-encapsulation of bioactive compounds using biopolymer and lipid-based transporters

MRI Shishir, L Xie, C Sun, X Zheng, W Chen - Trends in Food Science & …, 2018 - Elsevier
Background Bioactive compounds possess plenty of health benefits, but they are chemically
unstable and susceptible to oxidative degradation. The application of pure bioactive …