Linkers in the structural biology of protein–protein interactions
VP Reddy Chichili, V Kumar, J Sivaraman - Protein science, 2013 - Wiley Online Library
Linkers or spacers are short amino acid sequences created in nature to separate multiple
domains in a single protein. Most of them are rigid and function to prohibit unwanted …
domains in a single protein. Most of them are rigid and function to prohibit unwanted …
[HTML][HTML] Chromatin challenges during DNA replication and repair
A Groth, W Rocha, A Verreault, G Almouzni - Cell, 2007 - cell.com
Inheritance and maintenance of the DNA sequence and its organization into chromatin are
central for eukaryotic life. To orchestrate DNA-replication and-repair processes in the context …
central for eukaryotic life. To orchestrate DNA-replication and-repair processes in the context …
α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
E Kontopoulos, JD Parvin… - Human molecular …, 2006 - academic.oup.com
Abstract α-synuclein is a neuronal protein implicated genetically in Parkinson's disease. α-
synuclein localizes to the nucleus and presynaptic nerve terminals. Here we show that α …
synuclein localizes to the nucleus and presynaptic nerve terminals. Here we show that α …
Histone chaperones: assisting histone traffic and nucleosome dynamics
ZA Gurard-Levin, JP Quivy… - Annual review of …, 2014 - annualreviews.org
The functional organization of eukaryotic DNA into chromatin uses histones as components
of its building block, the nucleosome. Histone chaperones, which are proteins that escort …
of its building block, the nucleosome. Histone chaperones, which are proteins that escort …
Regulation of replication fork progression through histone supply and demand
DNA replication in eukaryotes requires nucleosome disruption ahead of the replication fork
and reassembly behind. An unresolved issue concerns how histone dynamics are …
and reassembly behind. An unresolved issue concerns how histone dynamics are …
Molecular dissection of formation of senescence-associated heterochromatin foci
R Zhang, W Chen, PD Adams - Molecular and cellular biology, 2007 - Am Soc Microbiol
Senescence is characterized by an irreversible cell proliferation arrest. Specialized domains
of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF) …
of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF) …
The genomes of three uneven siblings: footprints of the lifestyles of three Trichoderma species
M Schmoll, C Dattenböck… - Microbiology and …, 2016 - Am Soc Microbiol
The genus Trichoderma contains fungi with high relevance for humans, with applications in
enzyme production for plant cell wall degradation and use in biocontrol. Here, we provide a …
enzyme production for plant cell wall degradation and use in biocontrol. Here, we provide a …
[HTML][HTML] Structural basis for the histone chaperone activity of Asf1
CM English, MW Adkins, JJ Carson, MEA Churchill… - Cell, 2006 - cell.com
Summary Anti-silencing function 1 (Asf1) is a highly conserved chaperone of histones H3/H4
that assembles or disassembles chromatin during transcription, replication, and repair. The …
that assembles or disassembles chromatin during transcription, replication, and repair. The …
Structure of C3b reveals conformational changes that underlie complement activity
Resistance to infection and clearance of cell debris in mammals depend on the activation of
the complement system, which is an important component of innate and adaptive immunity …
the complement system, which is an important component of innate and adaptive immunity …